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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG2 All Species: 24.24
Human Site: Y759 Identified Species: 48.48
UniProt: P16885 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16885 NP_002652.2 1265 147870 Y759 L Y D V S R M Y V D P S E I N
Chimpanzee Pan troglodytes XP_001147944 1265 147906 Y759 L Y D V S R M Y V D P S E I N
Rhesus Macaque Macaca mulatta XP_001111677 1265 147898 Y759 L Y D V S R M Y V D P S E I N
Dog Lupus familis XP_546812 1252 146274 Y759 L Y D V S R M Y V D P S E I N
Cat Felis silvestris
Mouse Mus musculus Q8CIH5 1265 147573 Y759 L Y D V S R M Y V D P S E I N
Rat Rattus norvegicus P24135 1265 147716 Y759 L Y D V S R M Y V D P S E I N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508105 991 115582 R498 I N P S T P Q R T V K A L Y D
Chicken Gallus gallus Q2VRL0 637 72514 D144 I R Y M S S E D C T I F K K E
Frog Xenopus laevis Q32NH8 758 87399 S265 A K K L H A M S I D G F L V Y
Zebra Danio Brachydanio rerio A5D6R3 784 89362 G291 N L F M T Q N G F T M Y M L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624101 1134 132613 I641 N K I K H C R I K L E G R L Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 R447 L Y D Y K A Q R E D E L S F C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98 94.4 N.A. 94.1 94.7 N.A. 62.7 20.7 22.1 21.2 N.A. N.A. 40.9 N.A. 32.9
Protein Similarity: 100 99.9 99.2 97 N.A. 97.1 97.3 N.A. 67.8 33.2 37.5 34.9 N.A. N.A. 59.1 N.A. 49
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 6.6 13.3 0 N.A. N.A. 0 N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 26.6 33.3 33.3 N.A. N.A. 6.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 0 17 0 0 0 0 0 9 0 0 0 % A
% Cys: 0 0 0 0 0 9 0 0 9 0 0 0 0 0 9 % C
% Asp: 0 0 59 0 0 0 0 9 0 67 0 0 0 0 9 % D
% Glu: 0 0 0 0 0 0 9 0 9 0 17 0 50 0 9 % E
% Phe: 0 0 9 0 0 0 0 0 9 0 0 17 0 9 0 % F
% Gly: 0 0 0 0 0 0 0 9 0 0 9 9 0 0 0 % G
% His: 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 17 0 9 0 0 0 0 9 9 0 9 0 0 50 0 % I
% Lys: 0 17 9 9 9 0 0 0 9 0 9 0 9 9 0 % K
% Leu: 59 9 0 9 0 0 0 0 0 9 0 9 17 17 0 % L
% Met: 0 0 0 17 0 0 59 0 0 0 9 0 9 0 0 % M
% Asn: 17 9 0 0 0 0 9 0 0 0 0 0 0 0 50 % N
% Pro: 0 0 9 0 0 9 0 0 0 0 50 0 0 0 0 % P
% Gln: 0 0 0 0 0 9 17 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 0 0 0 50 9 17 0 0 0 0 9 0 0 % R
% Ser: 0 0 0 9 59 9 0 9 0 0 0 50 9 0 9 % S
% Thr: 0 0 0 0 17 0 0 0 9 17 0 0 0 0 0 % T
% Val: 0 0 0 50 0 0 0 0 50 9 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 59 9 9 0 0 0 50 0 0 0 9 0 9 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _